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(+)-Corynoline
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
(+)-Corynoline图片
CAS NO:18797-79-0
包装:20mg
市场价:1620元

产品介绍
(+)-Corynoline 是一种可逆的非竞争性乙酰胆碱酯酶 (AChE) 抑制剂，IC50 为 30.6 μM。
Cas No.18797-79-0
别名紫蓳灵
化学名5b,13-dimethyl-5b,6,7,12b,13,14-hexahydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-c][1,3]dioxolo[4,5-i]phenanthridin-6-ol
Canonical SMILES[H]C1(C2=C([H])C3=C4OC([H])([H])O3)N(C([H])([H])[H])C([H])([H])C5=C(C([H])=C([H])C6=C5OC([H])([H])O6)C1(C([H])([H])[H])C(C([H])([H])C2=C4[H])([H])O[H]
分子式C21H21NO5
分子量367.14
溶解度Chloroform: 10 mg/ml,DMF: slightly soluble,Ethanol: slightly soluble
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Corynoline, isolated from Corydalis incise (Papaveraceae), is a reversible and noncompetitive acetylcholinesterase (AChE) inhibitor with an IC50 of 30.6 μM[1]. Corynoline exhibits anti-inflammatory activity by activating Nrf2[2].

References:
[1]. Kim DK. Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase. Arch Pharm Res. 2002 Dec;25(6):817-9.
[2]. Liu B, et al. Corynoline Exhibits Anti-inflammatory Effects in Lipopolysaccharide (LPS)-Stimulated Human Umbilical Vein Endothelial Cells through Activating Nrf2. Inflammation. 2018 Oct;41(5):1640-1647.