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Esomeprazole
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Esomeprazole图片
CAS NO:119141-88-7
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议

产品介绍
Esomeprazole ((S)-Omeprazole) 是一种有效且具有口服活性的质子泵抑制剂,通过抑制胃壁细胞中的 H+, K+-ATPase 来减少酸分泌。
Cas No.119141-88-7
别名埃索美拉唑镁,(S)-Omeprazole; (-)-Omeprazole
Canonical SMILESCOC1=CC=C2C(N=C([S@](CC3=C(C)C(OC)=C(C)C=N3)=O)N2)=C1
分子式C17H19N3O3S
分子量345.4
溶解度DMF: 30 mg/ml,DMSO: 20 mg/ml,Ethanol: 10 mg/ml,PBS (pH 7.2): 10 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Esomeprazole is an inhibitor of the gastric H+/K+-ATPase and the (S) enantiomer of omeprazole .1It reversibly inhibits the activity of the H+/K+-ATPase in an enzyme assay. Esomeprazole (30 mg/kg, s.c.) inhibits histamine-induced gastric acid secretion in rats. Formulations containing esomeprazole in complex with magnesium have been used as proton pump inhibitors (PPIs) in the treatment of gastroesophageal reflux disease (GERD),H. pylorieradication, and hypersecretory conditions, as well as in the prevention of non-steroidal anti-inflammatory drug-related gastric ulcer.

1.Shin, J.M., and Sachs, G.Restoration of acid secretion following treatment with proton pump inhibitorsGastroenterology123(5)1588-1597(2002)