| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| Canonical SMILES | CC1=C(C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])OC3=C(C(OCCN4CCCCC4)=O)C=CC=C3C1=O |
| 分子式 | C24H20D5NO4 |
| 分子量 | 396.5 |
| 溶解度 | Acetonitrile: soluble,DMSO: soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Flavoxate-d5is intended for use as an internal standard for the quantification of flavoxate by GC- or LC-MS. Flavoxate is an inhibitor of L-type calcium channels and an antimuscarinic agent.1It induces relaxation of potassium-precontracted isolated human urinary bladder detrusor muscle (IC50= 2 µM) and reduces contractions induced by the acetylcholine receptor agonist carbachol or calcium in isolated rat detrusor strips.1,2Microinjection of flavoxate (0.68 µg/animal) into the oral pontine reticular nucleus inhibits reflex micturition in decerebrated cats, and intravenous or intracerebroventricular administration reduces isovolumetric rhythmic bladder contractions in rats.2Formulations containing flavoxate have previously been used in the treatment of frequent or urgent urination, increased nocturnal urination, bladder pain, and urinary incontinence. 1.Tomoda, T., Aishima, M., Takano, N., et al.The effects of flavoxate hydrochloride on voltage-dependent L-type Ca2+ currents in human urinary bladderBrit. J. Pharmacol.146(1)25-32(2005) 2.Kimura, Y., Sasaki, Y., Hamada, K., et al.Mechanisms of the suppression of the bladder activity by flavoxateInt. J. Urol.3(3)218-227(1996) |
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