| 包装 | 价格(元) |
| 500 µg | 电议 |
| 1mg | 电议 |
| 5mg | 电议 |
| Canonical SMILES | OC(C1=CC=CC=C1)(CCCN2C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C2([2H])[2H])C3=CC=CC=C3 |
| 分子式 | C21H17D10NO |
| 分子量 | 319.5 |
| 溶解度 | DMSO: soluble,Methanol: soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Diphenidol-d10is intended for use as an internal standard for the quantification of diphenidol by GC- or LC-MS. Diphenidol is an antagonist of muscarinic acetylcholine receptors (mAChRs; Kis = 0.43, 2.8, 1.1, 0.91, and 1.28 µM in CHO cell membranes expressing M1-5receptors, respectively).1It also inhibits Kvchannels in Neuro2A cells (IC50= 28.2 µM), as well as L-type voltage-gated calcium channels in differentiated NG 108-15 cells in a concentration-dependent manner.2Microiontophoretic application of diphenidol inhibits rotation-induced firing of medial vestibular nucleus neurons in a cat model of vertigo.3Diphenidol (3.2 mg/kg, i.v.) prevents apomorphine-induced emesis in dogs.4Formulations containing diphenidol have been used in the treatment of vertigo and as antiemetics. 1.Varoli, L., Andreani, A., Burnelli, S., et al.Diphenidol-related diamines as novel muscarinic M4 receptor antagonistsBioorg. Med. Chem. Lett.18(9)2972-2976(2008) 2.Leung, Y.M., Wong, K.L., Cheng, K.S., et al.Inhibition of voltage-gated K+ channels and Ca2+ channels by diphenidolPharmacol. Rep.64(3)739-744(2012) 3.Kawabata, A., Sasa, M., Kishimoto, T., et al.Effects of anti-vertigo drugs on medial vestibular nucleus neurons activated by horizontal rotationJpn. J. Pharmacol.55(1)101-106(1991) 4.Nakayama, H., Yamakuni, H., Nakayama, A., et al.Diphenidol has no actual broad antiemetic activity in dogs and ferretsJ. Pharmacol. Sci.96(3)301-306(2004) |
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