| CAS NO: | 53818-10-3 |
| 包装: | 1mg |
| 市场价: | 3614元 |
| Cas No. | 53818-10-3 |
| Canonical SMILES | O=C1N2C=CC=CC2=NN1CCCN3CCN(CC3)C4=CC=C(C(Cl)=C4)O |
| 分子式 | C19H22ClN5O2 |
| 分子量 | 387.9 |
| 溶解度 | Chloroform: slightly soluble,Methanol: slightly, sonicated |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 4’-hydroxy Trazodone is a metabolite of the antidepressant and sedative trazodone.1It is an inhibitor of organic anion transporter 3 (OAT3; Ki= 16.9 µM) and is selective for OAT3 over OAT1 (Ki= >200 µM).2 1.Yamato, C., Takahashi, T., Fujita, T., et al.Studies on metabolism of trazodone, II. Metabolic fate after intravenous administration and effects on liver microsomal drug-metabolizing enzymes in ratsXenobiotica4(12)765-777(1974) 2.Zou, L., Matsson, P., Stecula, A., et al.Drug metabolites potently inhibit renal organic anion transporters, OAT1 and OAT3J. Pharm. Sci.110(1)347-353(2021) |
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