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GSK 417651A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GSK 417651A图片
CAS NO:736945-96-3
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
GSK 417651A 是一种有效的经典瞬时受体通道 (TRPC3/6) 选择性阻断剂,对 hTRPC3 和 hTRPC6 具有阻断效力,IC50 值分别为 1260 nM 和 500 nM。
Cas No.736945-96-3
Canonical SMILESO=C(C1=CSC(NC2=CC=C(OC)C=C2)=N1)N(C3)CCC4=C3C=CC=C4
分子式C20H19N3O2S
分子量365.5
溶解度DMSO: soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

GSK 417651A is an inhibitor of transient receptor potential canonical 3 (TRPC3) and TRPC6 (IC50=~0.4 µM for both).1It inhibits migration of isolated human fibroblastic valve interstitial cells into the wounded area in a scratch test assay when used at a concentration of 2 µM.2

1.Xu, X., Lozinskaya, I., Costell, M., et al.Characterization of small molecule TRPC3 and TRPC6 agonist and antagonistsBiophys. J.104(2)454A(2013) 2.Al-Shammari, H., Latif, N., Sarathchandra, P., et al.Expression and function of mechanosensitive ion channels in human valve interstitial cellsPLoS One15(10)e0240532(2020)