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Dopamine-d4(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dopamine-d4(hydrochloride)图片
CAS NO:203633-19-6
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
An internal standard for the quantification of dopamine
Cas No.203633-19-6
别名盐酸多巴胺D4,ASL279-d4
Canonical SMILESNC([2H])([2H])C([2H])([2H])C1=CC(O)=C(C=C1)O.Cl
分子式C8H7D4NO2• HCl
分子量193.7
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 5 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Dopamine-d4is intended for use as an internal standard for the quantification of dopamine by GC- or LC-MS. Dopamine is an endogenous catecholamine neurotransmitter synthesized from the amino acid L-tyrosine that acts as an agonist at dopamine receptors (D1-5).1Dopamine is mainly synthesized in the substantia nigra and ventral tegmental area, and is a precursor in norepinephrine and epinephrine biosynthesis. Dopamine-containing neurons in the brain are involved in reward-motivated behavior, motor control, and hormone release. Dopamine is also synthesized in the adrenal glands where it exerts peripheral paracrine functions including control of vasodilation, sodium excretion, insulin production, gastrointestinal motility, and the activity of lymphocytes.2,3Loss or damage of dopaminergic neurons in the substancia nigra is associated with Parkinson’s disease.4

1.Missale, C., Nash, S.R., Robinson, S.W., et al.Dopamine receptors: From structure to functionPhysiol. Rev.78(1)190-225(1998) 2.Hayaishi, O.Molecular genetic studies on sleep-wake regulation, with special emphases on the prostaglandin D2 systemJ. Appl. Physiol.92(2)863-868(2015) 3.Garza, J.H.H., and Carr, D.J.J.Neuroendocrine peptide receptors on cells of the immune systemChem. Immunol.69132-154(1997) 4.Angeles, D.C., Ho, P., Dymock, B.W., et al.Antioxidants inhibit neuronal toxicity in Parkinson’s disease-linked LRRK2Ann. Clin. Transl. Neurol.3(4)288-294(2016)