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Dynorphin A(trifluroacetate salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Dynorphin A(trifluroacetate salt)图片
包装与价格：
包装价格(元)
500 µg电议
1mg电议
5mg电议
10mg电议

产品介绍
An endogenous opioid receptor agonist
Canonical SMILESO=C(N[C@@H](CC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@H](C(O)=O)CCC(N)=O)=O)=O)[C@@H](NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CCC1)N1C([C@H](CCCNC(N)=N)NC([C@@]([C@@H](C)CC)([H])NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@@H](NC(CNC(CNC([C@@H](N)CC2=CC=C(O)C=C2)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC4=CNC5=CC=CC=C45.FC(F)(C(O)=O)F
分子式C99H155N31O23• XCF3COOH
分子量2147.5
溶解度DMF: 30 mg/mL,DMSO: 30 mg/mL,PBS (pH 7.2): 5 mg/mL
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Dynorphin A is a heptadecapeptide released from the cleavage of prodynorphin and found widely distributed in the central nervous system, where it is implicated in antinociceptive functions.1,2,3It acts as an opioid receptor agonist with nanomolar binding affinity to the three major isotypes κ, µ, and δ (Kis = 0.5-1 nM) and has also been shown to activate human ORL1, a novel opioid receptor-like receptor (Ki= 386 nM).4

1.Berman, Y., Juliano, L., and Devi, L.A.Specificity of the dynorphin-processing endoprotease: Comparison with prohormone convertasesJ. Neurochem.72(5)2120-2196(1999) 2.Janecka, A., Fichna, J., and Janecki, T.Opioid receptors and their ligandsCurr. Top. Med. Chem.4(1)1-17(2004) 3.Dhawan, B.N., Cesselin, F., Raghubir, R., et al.International Union of Pharmacology. XII. Classification of opioid receptorsPharmacol. Rev.48(4)567-592(1996) 4.Zhang, S., Tong, Y., Tian, M., et al.Dynorphin A as a potential endogenous ligand for four members of the opioid receptor gene familyJ. Pharmacol. Exp. Ther.286(1)136-141(1998)