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Larixyl Acetate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Larixyl Acetate图片
CAS NO:4608-49-5
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
Larixyl acetate 是一种有效的选择性 TRPC6 抑制剂,对 hTRPC6-YFP 和 hTRPC3-YFP 的 IC50 值分别为 0.58 μM 和 6.83 μM。
Cas No.4608-49-5
Canonical SMILESC[C@]12[C@@](C(C)(CCC2)C)([H])[C@H](CC([C@@H]1CC[C@](C)(O)C=C)=C)OC(C)=O
分子式C22H36O3
分子量348.5
溶解度Chloroform: slightly soluble,Ethyl Acetate: slightly soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Larixyl acetate is a diterpenoid that has been found inLarixand has transient receptor potential canonical 6 (TRPC6) inhibitory and analgesic activities.1,2It inhibits the activity of TRPC6 (IC50= 0.58 µM) and is selective for TRPC6 over TRPC3 (IC50= 6.83 µM), as well as over nine additional TRP channels at 10 µM.1Intrathecal administration of larixyl acetate reduces mechanical and cold allodynia in a rat model of neuropathic pain induced by spared nerve injury (SNI).

1.Urban, N., Wang, L., Kwiek, S., et al.Identification and validation of larixyl acetate as a potent TRPC6 inhibitorMol. Pharmacol.89(1)197-213(2016) 2.Wang, J., Zhao, M., Jia, P., et al.The analgesic action of larixyl acetate, a potent TRPC6 inhibitor, in rat neuropathic pain model induced by spared nerve injuryJ. Neuroinflammation17(1)118(2020)