| CAS NO: | 4294-45-5 |
| 包装 | 价格(元) |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| Cas No. | 4294-45-5 |
| 别名 | D,L-苏-Β-羟基天门冬氨酸 |
| Canonical SMILES | OC([C@@H](O)[C@H](N)C(O)=O)=O |
| 分子式 | C4H7NO5 |
| 分子量 | 149.1 |
| 溶解度 | Acetonitrile: Slightly soluble,Chloroform: Slightly soluble,DMF: Slightly soluble,DMSO: Slightly soluble,Ethanol: Slightly soluble,PBS (pH 7.2): Slightly soluble,Water: Slightly soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | DL-threo-β-Hydroxyaspartic acid is an inhibitor of excitatory amino acid transporters (EAATs).1,2It inhibits glutamate uptake in COS-1 cells expressing human EAAT1 or EAAT2 (IC50s = 96 and 31 µM, respectively) as well as inward currents induced by L-aspartate in EAAT4-expressingXenopusoocytes (Ki= 0.6 µM) and by L-glutamate in EAAT5-expressing oocytes (Ki= 2.5 µM) voltage-clamped at -60 mV. Intrathecal administration of DL-threo-β-hydroxyaspartic acid (7.5 and 15 µg/animal) reduces the number of flinches and shakes in the second phase of the formalin test in rats.3 1.Shimamoto, K., Lebrun, B., Yasuda-Kamatani, Y., et al.??-threo-β-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters.Mol. Pharmacol.53(2)195-201(1998) 2.Shigeri, Y., Shimamoto, K., Yasuda-Kamatani, Y., et al.Effects of threo-β-hydroxyaspartate derivatives on excitatory amino acid transporters (EAAT4 and EAAT5)J. Neurochem.79(2)297-302(2001) 3.Yaster, M., Guan, X., Petralia, R.S., et al.Effect of inhibition of spinal cord glutamate transporters on inflammatory pain induced by formalin and complete Freund’s adjuvantAnesthesiology114(2)412-423(2011) |
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