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Choline-d9(chloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Choline-d9(chloride)图片
CAS NO:61037-86-3
包装与价格:
包装价格(元)
500mg电议
1 g电议

产品介绍
An internal standard for the quantification of choline
Cas No.61037-86-3
别名氯化胆碱 d9 (氯化物)
Canonical SMILES[2H]C([2H])([2H])[N+](C([2H])([2H])[2H])(C([2H])([2H])[2H])CCO.[Cl-]
分子式C5H5D9NO • Cl
分子量148.7
溶解度DMSO: slightly soluble,Ethanol: 2 mg/ml,PBS (pH 7.2): 2 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Choline-d9is intended for use as an internal standard for the quantification of choline by GC- or LC-MS. Choline is an essential nutrient with roles in liver, neurological, hematological, and skeletal muscle homeostasis.1,2,3,4It is a precursor in the biosynthesis of membrane phospholipids, such as phosphatidylcholine, which facilitate cell signaling and transport across the membrane, and a precursor to the neurotransmitter acetylcholine. Choline is required for hepatic lipid transport.1Perinatal administration of choline (18.8 mg/kg) improves prenatal alcohol exposure-induced cognitive deficits in rats.2Choline (13 mg/animal per day) improves motor coordination and behavioral deficits in a mouse model of Rett syndrome, as well as improves deficits in recognition memory induced by early-life iron deficiency in rats when administered in the drinking water at a concentration of 5 ppm.3Deficiencies in choline intake are positively correlated with muscle wasting, and dietary administration of choline (1,000 mg/kg) increases leg and breast muscle protein content in broiler chickens.4

1.Sanders, L.M., and Zeisel, S.H.Choline: Dietary requirements and role in brain developmentNutr. Today42(4)181-186(2007) 2.Thomas, J.D., Garrison, M., and O’Neill, T.M.Perinatal choline supplementation attenuates behavioral alterations associated with neonatal alcohol exposure in ratsNeurotoxicol. Teratol.26(1)35-45(2004) 3.Derbyshire, E., and Obeid, R.Choline, neurological development and brain function: A systematic review focusing on the first 1000 daysNutrients12(6)1731(2020) 4.Moretti, A., Paoletta, M., Liguori, S., et al.Choline: An essential nutrient for skeletal muscleNutrients12(7)E2144(2020)