| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Canonical SMILES | N1(C2=NC=NC(O[C@H]3C[C@@H](N4C=CC=N4)C3)=C2)C[C@H](C5=CC=CC=C5)OCC1 |
| 分子式 | C21H23N5O2 |
| 分子量 | 377.4 |
| 溶解度 | Ethanol: 25 mg/ml |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | ELOVL1-22 is an inhibitor of ELOVL fatty acid elongase 1 (ELOVL1).1It reduces lysohexacosanoylphosphatidylcholine (LPC(C26:0)) synthesis in HEK293 cells (IC50= 400 pM), a marker of ELOVL1 inhibition, and is selective for ELOVL1 over ELOVL4, -6, and -7 (IC50s = >50 µM for all), as well as a panel of 34 receptors at 10 µM. ELOVL1-22 (1-32 mg/kg) reduces blood and CNS levels of LPC(C26:0) in anAbcd1-/-mouse model of adrenoleukodystrophy (ALD), a neurodegenerative disease characterized by rapid inflammatory demyelination of the CNS. 1.Boyd, M.J., Collier, P.N., Clark, M.P., et al.Discovery of novel, orally bioavailable pyrimidine ether-based inhibitors of ELOVL1J. Med. Chem.64(24)17777-17794(2021) |
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