| 包装 | 价格(元) |
| 500 µg | 电议 |
| 1mg | 电议 |
| Canonical SMILES | O=S(CCC1=CC=C(NC=C2CC3N(C([2H])([2H])[2H])CCC3)C2=C1)(C4=CC=CC=C4)=O.Br |
| 分子式 | C22H23D3N2O2S • HBr |
| 分子量 | 466.5 |
| 溶解度 | DMSO: Soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | rac-Eletriptan-d3is intended for use as an internal standard for the quantification of eletriptan by GC- or LC-MS. Eletriptan is an agonist of the serotonin (5-HT) receptor types 5-HT1Band 5-HT1D.1It inhibits forskolin-induced cAMP accumulation in and induces vasoconstriction of isolated rabbit common carotid artery rings (pD2s = 7.6 and 4.9, respectively), an effect that can be blocked by the 5-HT1Bantagonist SB216641 but not the 5-HT1Dantagonist BRL15572. Eletriptan preferentially induces constriction of isolated human cerebral over coronary arteries (EC50s = 15.8 and 1,995 nM, respectively).2Formulations containing eletriptan have been used in the treatment of migraine headache. 1.Akin, D., Onaran, H.O., and Gudal, H.Agonist-directed trafficking explaining the difference between response pattern of naratriptan and sumatriptan in rabbit common carotid arteryBr. J. Pharmacol.136(2)171-176(2002) 2.Edvinsson, L., Uddman, E., Wackenfors, A., et al.Triptan-induced contractile (5-HT1B receptor) responses in human cerebral and coronary arteries: Relationship to clinical effectClin. Sci. (Lond.)109(3)335-342(2005) |
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