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STING agonist-12
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
STING agonist-12图片
CAS NO:2259624-71-8
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
STING agonist-12 (Compound 53) 是一种口服有效的人 STING 激活剂，EC50 为 185 nM。
Cas No.2259624-71-8
分子式C25H19ClF4N2O2
分子量490.88
溶解度DMSO : 250 mg/mL (509.29 mM; Need ultrasonic)
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

STING agonist-12 (Compound 53) is a potent, orally active human STING activator with an EC50 of 185 nM[1].

STING agonist-12 (Compound 53) (10 μM) shows excellent pan-polymorph activity across the panel of STING proteins (92%, 107% and 92% against R232, H232 and HAQ, respectively) in HEK293T cells[1].STING agonist-12 is not active at mouse STING[1].

STING agonist-12 (Compound 53) (5 mpk for i.v.; 10 mpk for p.o.) is well-absorbed with a short terminal half-life[1].

[1]. Pryde DC, et al. The discovery of potent small molecule activators of human STING. Eur J Med Chem. 2021 Jan 1;209:112869.