| CAS NO: | 1189477-66-4 |
| 包装: | 1mg |
| 市场价: | 4158元 |
| Cas No. | 1189477-66-4 |
| 别名 | 尼鲁米特D6 |
| Canonical SMILES | O=C1N(C2=CC(C(F)(F)F)=C([N+]([O-])=O)C=C2)C(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])N1)=O |
| 分子式 | C12H4D6F3N3O4 |
| 分子量 | 323.3 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Nilutamide-d6 is intended for use as an internal standard for the quantification of nilutamide by GC- or LC-MS. Nilutamide is a non-steroidal antiandrogen that is an antagonist of the androgen receptor.1 It reverses testosterone-induced increases in cell proliferation with an IC50 value of 412 nM in mouse mammary carcinoma cells in vitro.2 It has antiandrogenic activity in both intact and castrated rats, inhibiting testosterone propionate-induced prostate growth when administered at a dose of 2.5 mg/kg.3 Formulations containing nilutamide have been used in combination with surgical castration in the treatment of metastatic prostate cancer. |1. Signh, S.M., Gauthier, S., and Labrie, F. Androgen receptor antagonists (antiandrogens): Structure-activity relationships. Curr. Med. Chem. 7(2), 211-247 (2000).|2. Simard, J., Singh, S.M., and Labrie, F. Comparison of in vitro effects of the pure antiandrogens OH-flutamide, Casodex, and nilutamide on androgen-sensitive parameters. Urology 49(4), 580-586 (1997).|3. Wakeling, A.E., Furr, B.J.A., Glen, A.T., et al. Receptor binding and biological activity of steroidal and nonsteroidal antiandrogens. J. Steroid Biochem. 15, 355-359 (1981). |
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