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Butyric Acid-d7
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Butyric Acid-d7图片
CAS NO:73607-83-7
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
An internal standard for the quantification of sodium butyrate
Cas No.73607-83-7
别名氘代丁酸(D7),Butanoic acid-d7
Canonical SMILESOC(C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O
分子式C4HD7O2
分子量95.1
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Butyric acid-d7 is intended for use as an internal standard for the quantification of sodium butyrate by GC- or LC-MS. Butyric acid is a short-chain fatty acid.[1] It is produced predominately by bacterial fermentation of dietary fiber in the colon but has also been identified in mammalian milk.[1],[2] Butyric acid is an inhibitor of histone deacetylase (HDAC; IC50 = 90 μM in a cell-free assay).[3] It induces differentiation, cell cycle arrest at the G0 phase, and apoptosis, as well as inhibits proliferation, in a variety of cancer cells when used at concentrations ranging from 0.6 to 100 mM.[2],[5],[6] Butyric acid decreases the expression of IFN-γ-related signaling genes and metastatic genes in H460 human lung cancer cells when used at a concentration of 2 mM.[5] It reduces tumor growth in a CaSki mouse xenograft model when administered at doses of 200 and 800 mg/kg per day.[4] Butyric acid also reduces increases in colonic TNFa and Il6 expression and decreases colonic goblet cell depletion, tissue damage, muscle thickening, and cellular infiltration in a wild-type, but not Hcar2-/-, mouse model of TNBS-induced colitis.[7]

Reference:
[1]. Wang, M., Wichienchot, S., He, X., et al. In vitro colonic fermentation of dietary fibers: Fermentation rate, short-chain fatty acid production and changes in microbiota. Trends Food Sci. Technol. 88(1), 1-9 (2019).
[2]. Smith, J.G., Yokoyama, W.H., and German, J.B. Butyric acid from the diet: Actions at the level of gene expression. Crit. Rev. Food Sci. Nutr. 38(4), 259-297 (1998).
[3]. Waldecker, M., Kautenburger, T., Daumann, H., et al. Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon. J. Nutr. Biochem. 19(9), 587-593 (2008).
[4]. Decrion-Barthod, A.-Z., Bosset, M., Plissonnier, M.-L., et al. Sodium butyrate with UCN-01 has marked antitumour activity against cervical cancer cells. Anticancer Res. 30(10), 4049-4061 (2010).
[5]. Joseph, J., Mudduluru, G., Antony, S., et al. Expression profiling of sodium butyrate (NaB)-treated cells: identification of regulation of genes related to cytokine signaling and cancer metastasis by NaB. Oncogene 23(37), 6304-6315 (2004).
[6]. Chabanas, A., Khoury, E., Goeltz, P., et al. Effects of butyric acid on cell cycle regulation and induction of histone Hl° in mouse cells and tissue culture inducibility of Hl° in the late S-G2 phase of the cell cycle. J. Mol. Biol. 183(2), 141-151 (1985).|7. Chen, G., Ran, X., Li, B., et al. Sodium butyrate inhibits inflammation and maintains epithelium barrier integrity in a TNBS-induced inflammatory bowel disease mice model. EBioMedicine 30(1), 317-325 (2018).