您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > MK 386
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
MK 386
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MK 386图片
CAS NO:158493-17-5
包装:1mg
市场价:2867元

产品介绍
Potent, selective human type 1 5α-reductase inhibitor
Cas No.158493-17-5
Canonical SMILES[H][C@]1([C@@H](CCCC(C)C)C)CC[C@]2([C@@]3([C@H](C[C@]4(N(C(CC[C@@]4([C@]3(CC[C@]12C)[H])C)=O)C)[H])C)[H])[H]
分子式C28H49NO
分子量415.69
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Potent and selective human type 1 5α-reductase inhibitor (5αR1, IC50 = 0.9 nM). Exhibits 100-fold selectivity for 5αR1 over 5αR2 (IC50 = 154 nM). Supresses human serum and sebum dihydrotestosterone (DHT) levels in a dose-dependent manner without affecting semen DHT concentrations. Orally active.

Schwartz et al (1997) MK-386, an inhibitor of 5α-reductase type 1, reduces dihydrotestosterone concentrations in serum and sebum without affecting dihydrotestosterone concentrations in semen. J.Clin.Endocrinol.Metab. 82 1373 PMID:9141518 |Bakshi et al (1994) 4,7 beta-Dimethyl-4-azacholestan-3-one (MK-386) and related 4-azasteroids as selective inhibitors of human type 1 5 alpha-reductase. J.Med.Chem. 37 3871 PMID:7966146