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Antide(acetate)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Antide(acetate)图片
CAS NO:625092-10-6
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
A GnRHR antagonist
Cas No.625092-10-6
别名N-((4R,7R,10R,13S,16S,19R)-19-(((S)-1-(((S)-1-((S)-2-((R)-1-氨基-1-氧代丙烷-2-基)氨基甲酰基)吡咯烷-1-基)-6-(异丙基氨基)-1-氧代己基-2-基)氨基)-4-甲基-1-氧代戊烷-2-基)氨基甲酰基)-7-(4-氯苄基)-13-(羟甲基)-4-(萘-2-基甲基)-16-(4-(烟酰胺基)丁基)-2,5,8,11,14,17-六氧代-10-(吡啶-3-基甲基)-3,6,9,12,15,18-六氮杂二十三烷-23-基)烟酰胺乙酸盐
Canonical SMILESClC(C=C1)=CC=C1C[C@@H](NC([C@H](NC(C)=O)CC2=CC3=C(C=CC=C3)C=C2)=O)C(N[C@H](CC4=CN=CC=C4)C(N[C@@H](CO)C(N[C@@H](CCCCNC(C5=CN=CC=C5)=O)C(N[C@H](CCCCNC(C6=CN=CC=C6)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCNC(C)C)C(N7[C@@H](CCC7)C(N[C@H](C)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O.O=C(C)O
分子式C82H108ClN17O14.C2H4O2
分子量1651.3
溶解度DMSO: soluble,Ethanol: soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Antide is a third generation gonadotropin-releasing hormone receptor (GnRHR) antagonist.1,2,3,4It inhibits GnRH-induced secretion of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and gonadotropin in isolated rat pituitary cells when used at concentrations ranging from 0.001 to 1,000 nM but does not induce histamine release in isolated rat mast cells (EC50= >300 µg/ml).1,3Antide (250 µg/kg, i.v.) reduces serum LH and FSH levels in orchidectomized cynomolgus monkeys.2It inhibits ovulation in rats when administered at a dose of 2 µg/animal.3Antide (10 µg/animal, s.c.) reduces the intensity and duration of catalepsy induced by haloperidol in rats.4

1.Danforth, D.R., Williams, R.F., Gordon, K., et al.Inhibition of pituitary gonadotropin secretion by the gonadotropin-releasing hormone antagonist antide. I. In vitro studies on mechanism of actionEndocrinology128(4)2036-2040(1991) 2.Weinbauer, G.F., and Nieschlag, E.Comparison of the antigonadotropic activity of three GnRH antagonists (Nal-Glu, Antide and Cetrorelix) in a non-human primate model (Macaca fascicularis)Andrologia25(3)141-147(1993) 3.Flouret, G., Arnold, Z.S., Majewski, T., et al.Antiovulatory antagonists of LHRH related to antideJ. Pept. Sci.1(2)89-108(1995) 4.Umathe, S.N., Wanjari, M.M., Manna, S.S.S., et al.A possible participation of gonadotropin-releasing hormone in the neuroleptic and cataleptic effect of haloperidolNeuropeptides43(3)251-257(2009)