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Budesonide-d8
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Budesonide-d8图片
CAS NO:1105542-94-6
包装:1mg
市场价:4158元

产品介绍
An internal standard for the quantification of budesonide
Cas No.1105542-94-6
别名布地奈德 d8
Canonical SMILESC[C@@]12C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@]5([H])[C@@]4(C(CO)=O)OC(C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])([2H])O5)=CC(C=C1)=O
分子式C25H26D8O6
分子量438.6
溶解度Dichloromethane: slightly soluble,DMSO: slightly soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Budesonide-d8is intended for use as an internal standard for the quantification of budesonide by GC- or LC-MS. Budesonide is a glucocorticoid and an agonist of glucocorticoid receptors (EC50= 45.7 pM in a transactivation assay).1It is selective for glucocorticoid over mineralocorticoid receptors (EC50= 7,620 pM). Budesonide inhibits LPS-induced TNF-α release from human peripheral blood mononuclear cells (PBMCs; IC50= 0.96 nM).2It reduces levels of IL-1β and eotaxin in the lungs and the number of eosinophils and neutrophils in bronchoalveolar lavage fluid (BALF) in a rat model of ovalbumin-induced airway inflammation when administered at a dose of 3 mg/kg.3Intracolonic administration of budesonide decreases colon wet weight and colonic myeloperoxidase (MPO) activity in a rat model of oxazolone-induced colitis.4Formulations containing budesonide have been used in the treatment of Crohn's disease, ulcerative colitis, allergic rhinitis, and asthma.

1.Grossmann, C., Scholz, T., Rochel, M., et al.Transactivation via the human glucocorticoid and mineralocorticoid receptor by therapeutically used steroids in CV-1 cells: A comparison of their glucocorticoid and mineralocorticoid propertiesEur. J. Endocrinol.151(3)397-406(2004) 2.Millan, D.S., Ballard, S.A., Chunn, S., et al.Design and synthesis of long acting inhaled corticosteroids for the treatment of asthmaBioorg. Med. Chem. Lett.21(19)5826-5830(2011) 3.Birrell, M.A., Hardaker, E., Wong, S., et al.IκB kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthmaAm. J. Respir. Crit. Care Med.172(8)962-971(2005) 4.EkstrÖm, G.M.Oxazolone-induced colitis in rats: effects of budesonide, cyclosporin A, and 5-aminosalicylic acidScand. J. Gastroenterol.33(2)174-179(1998)