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Neuropeptide S(human)(acetate)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
包装与价格：
包装价格(元)
500 μg电议
1mg电议

产品介绍
A neuropeptide NSPR agonist
Canonical SMILES[H]N[C@@H](CO)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(NCC(N[C@@H](C(C)C)C(NCC(N[C@]([C@@H](C)O)([H])C(NCC(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CO)C(O)=O)=O)=O)C)=O)=O)=O)CC1=CC=CC=C1)=O)=O)=O)=O)=O)CCSC)=O)=O)=O)=O)=O)=O)=O)=O)CC2=CC=CC=C2)=O.CC(O)=O
分子式C93H155N31O28S.XC2H4O2
分子量2187.5
溶解度Water: 1 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Neuropeptide S is a neuropeptide expressed in the brain, primarily in glutamatergic neurons near the locus coeruleus and in the trigeminal sensory nucleus, as well as in neurons of the lateral parabrachial nucleus in rat brain.1It is an agonist of the neuropeptide S receptor (NPSR) with an EC50value of 9.4 nM for the human peptide to induce intracellular calcium mobilization in HEK293 cells expressing the human receptor.2Neuropeptide S (0.1-1 nmol), administered either intracerebroventricularly or into the paraventricular nucleus (PVN) of the hypothalamus, increases plasma adrenocorticotropic hormone (ACTH) and corticosterone levels in rats.3Administration into the PVN also decreases food intake in the hour following doses of 0.1, 0.3, and 1 nmol. Neuropeptide S decreases anxiety-like and fear behaviors in rodents, decreasing defensive burying in rats, increasing the time mice spend in the open arms of the elevated plus maze, and enhancing contextual fear extinction in mice.4,5

1.Xu, Y.-L., Gall, C.M., Jackson, V.R., et al.Distribution of neuropeptide S receptor mRNA and neurochemical characteristics of neuropeptide S-expressing neurons in the rat brainJ. Comp. Neurol.500(1)84-102(2007) 2.Xu, Y.-L., Reinscheid, R.K., Huitron-Resendiz, S., et al.Neuropeptide S: A neuropeptide promoting arousal and anxiolytic-like effectsNeuron43(4)487-497(2004) 3.Smith, K.L., Patterson, M.L., Dhillo, W.S., et al.Neuropeptide S stimulates the hypothalamo-pituitary-adrenal axis and inhibits food intakeEndocrinology147(7)3510-3518(2006) 4.Vitale, G., Filaferro, M., Ruggieri, V., et al.Anxiolytic-like effect of neuropeptide S in the rat defensive buryingPeptides29(12)2286-2291(2008) 5.JÜngling, K., Seidenbecher, T., Sosulina, L., et al.Neuropeptide S-mediated control of fear expression and extinction: Role of intercalated GABAergic neurons in the amygdalaNeuron59(2)298-310(2008)