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Olmesartan Medoxomil-d6
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Olmesartan Medoxomil-d6图片
CAS NO:1127298-67-2
包装与价格:
包装价格(元)
500 μg电议
1mg电议

产品介绍
奥美沙坦酯-d6 (CS 866-d6) 是氘标记的奥美沙坦酯。
Cas No.1127298-67-2
别名奥美沙坦酯 d6
Canonical SMILESCCCC1=NC(C(C([2H])([2H])[2H])(O)C([2H])([2H])[2H])=C(C(OCC(O2)=C(C)OC2=O)=O)N1CC3=CC=C(C4=CC=CC=C4C5=NN=NN5)C=C3
分子式C29H24D6N6O6
分子量564.6
溶解度DMSO: Slightly Soluble,Methanol: Slightly Soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Olmesartan medoxomil-d6is intended for use as an internal standard for the quantification of olmesartan medoxomil by GC- or LC-MS. Olmesartan medoxomil is an orally bioavailable prodrug form of olmesartan , a nonpeptide angiotensin II antagonist that is selective for the angiotensin 1 (AT1) receptor over the AT2receptor.1Olmesartan medoxomil (0.1 mg/kg) inhibits the angiotensin II pressor response in normotensive rats. It reduces both systolic and diastolic blood pressure in fructose-fed rats, a model of insulin resistance, when administered at a dose of 10 mg/kg per day, as well as in chow-fed control animals when administered at a dose of 11.4 mg/kg per day.2Olmesartan medoxomil also inhibits increases in plasma levels of triglycerides and non-esterified fatty acids in fructose-fed rats. Formulations containing olmesartan medoxomil have been used in the treatment of hypertension.

1.Mizuno, M., Sada, T., Ikeda, M., et al.Pharmacology of CS-866, a novel nonpeptide angiotensin II receptor antagonistEur. J. Pharmacol.285(2)181-188(1995) 2.Okada, K., Hirano, T., Ran, J., et al.Olmesartan medoxomil, an angiotensin II receptor blocker ameliorates insulin resistance and decreases triglyceride production in fructose-fed ratsHypertens. Res.27(4)293-299(2004)