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Raloxifene-d4(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Raloxifene-d4(hydrochloride)图片
CAS NO:1188263-47-9
包装与价格:
包装价格(元)
500 μg电议
1mg电议
5 mg电议

产品介绍
雷洛昔芬-d4(盐酸盐)是氘标记的雷洛昔芬。雷洛昔芬 (Keoxifene) 是苯并噻吩衍生的选择性雌激素受体调节剂 (SERM)。雷洛昔芬对骨骼和脂质具有雌激素激动作用,对乳房和子宫具有雌激素拮抗作用。雷洛昔芬用于乳腺癌和骨质疏松症研究。
Cas No.1188263-47-9
别名雷洛昔芬-D4,盐酸盐
Canonical SMILESOC1=CC=C(C(C(C2=CC=C(OC([2H])([2H])C([2H])([2H])N3CCCCC3)C=C2)=O)=C(C4=CC=C(O)C=C4)S5)C5=C1.Cl
分子式C28H23D4NO4S.HCl
分子量514.1
储存条件Store at 2°C to 8°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Raloxifene-d4is intended for use as an internal standard for the quantification of raloxifene by GC- or LC-MS. Raloxifene is a selective estrogen receptor modulator (SERM) that exhibits estrogenic activity in bone cells without stimulating breast or uterine tissues.1Raloxifene guards endothelial cells obtained from rat aortic rings against oxidative insult (1 µM) and lowers serum cholesterol in ovariectomized rodents (ED50= 0.2 mg/kg).2,1Formulations containing raloxifene have been shown to reduce bone resorption and promote bone formation in post-menopausal women.3

1.Black, L.J., Sato, M., Rowley, E.R., et al.Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized ratsJ. Clin. Invest.93(1)63-69(1994) 2.Wong, C.M., Yung, L.M., Leung, F.P., et al.Raloxifene protects endothelial cell function against oxidative stressBr. J. Pharmac.155(3)326-334(2008) 3.Özmen, B., Kirmaz, C., Aydin, K., et al.Influence of the selective oestrogen receptor modulator (raloxifene hydrochloride) on IL-6, TNF-α, TGF-ß1 and bone turnover markers in the treatment of postmenopausal osteoporosisEur. Cyto. Netw.18(3)148-153(2007)