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Thymulin(acetate hydrate)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Thymulin(acetate hydrate)图片
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
A peptide hormone
Canonical SMILESNC(C[C@@H](C(O)=O)NC([C@H](CO)NC(CNC(CNC([C@H](CCC(N)=O)NC([C@H](CO)NC([C@H](CCCCN)NC([C@H](C)NC([C@@H]1CCC(N1)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C)=O.O
分子式C33H54N12O15•XC2H4O2[XH2O]
分子量858.9
溶解度DMSO: slightly soluble,PBS (pH 7.2): 10 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Thymulin is a zinc-dependent metallopeptide hormone with immunomodulatory, anti-inflammatory, and analgesic activities.1,2It is primarily produced by thymic epithelial cells but can be produced by macrophages and fibroblasts when exposed to extracellular stressors, such as heat or oxidative stress.2Thymulin potentiates mitogen-induced proliferation of IL-2 receptor-positive mature T cells.3It reduces pro-inflammatory cytokine production in rodent models of LPS- or endotoxin-induced systemic inflammation, as well as prevents myocardial inflammation in a mouse model of encephalomyocarditis virus-induced myocarditis and suppresses autoantibody production in a mouse model of reovirus-induced thyroiditis.4,5Thymulin (0.1, 0.5, and 1 µg, i.c.v.) prevents endotoxin-induced hyperalgesia in rats.5

1.Bach, J.-F., and Dardenne, M.Thymulin, a zinc-dependent hormoneMed. Oncol. Tumor Pharmacother.6(1)25-29(1989) 2.Lunin, S.M., Khrenov, M.O., Glushkova, O.V., et al.Extrathymic production of thymulin induced by oxidative stress, heat shock, apoptosis, or necrosisInt. J. Immunopathol. Pharmacol.30(1)58-69(2017) 3.Hadden, J.W.Thymic endocrinologyAnn. N.Y. Acad. Sci.840(1)352-358(1998) 4.Santos, M.A.M., Henriques-Coelho, T., and Leite-Moreira, A.Immunomodulatory role of thymulin in lung diseasesExpert Opin. Ther. Targets14(2)131-141(2010) 5.Safieh-Garabedian, B., Ochoa-Chaar, C.I., Poole, S., et al.Thymulin reverses inflammatory hyperalgesia and modulates the increased concentration of proinflammatory cytokines induced by i.c.v. endotoxin injectionNeuroscience121(4)865-873(2003)