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3,3',5-Triiodo-L-thyronine(sodium salt hydrate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
3,3',5-Triiodo-L-thyronine(sodium salt hydrate)图片
CAS NO:345957-19-9
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
3,3',5-Triiodo-L-thyronine (sodium salt hydrate) 是甲状腺激素的一种活性形式。
Cas No.345957-19-9
别名三碘代甲状腺素钠盐水合物; Triiodothyronine sodium hydrate; 3,3',5-Triiodo-L-thyronine sodium hydrate; T3 sodium hydrate
Canonical SMILESIC1=C(OC2=CC(I)=C(O)C=C2)C(I)=CC(C[C@@H](C([O-])=O)N)=C1.[Na+].O
分子式C15H11I3NO4•Na [XH2O]
分子量673
溶解度DMF: 0.25 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 1 mg/ml
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

3,3',5-Triiodo-L-thyronine (T3) is a thyroid hormone.1It is produced by 5'-monodeiodination of the prohormone thyroxine (T4) in various tissues, including liver and kidney. T3 is an agonist of thyroid hormone receptors TRα and TRβ (Kis = 2.3 nM for both) that modulates diverse biological properties, including metabolism, cardiac function, growth, and redox signaling.2,3,4,5It also functions as an inhibitor of L-type amino acid transporter 1 (LAT1), inhibiting LAT1-mediated leucine uptake in HEK293 cells when used at a concentration of 10 µM.6

1.Larsen, P.R., Silva, J.E., and Kaplan, M.M.Relationships between circulating and intracellular thyroid hormones: Physiological and clinical implicationsEndocr. Rev.2(1)87-102(1981) 2.Shiohara, H., Nakamura, T., Kikuchi, N., et al.Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemiaBioorgan. Med. Chem.20(11)3622-3634(2012) 3.Cox, M.D., Dalal, S.S., Heard, C.R.C., et al.Metabolic rate and thyroid status in rats fed diets of different protein-energy value: The importance of free T3J. Nutri.114(9)1609-1616(1984) 4.Macchia, P.E., Takeuchi, Y., Kawai, T., et al.Increased sensitivity to thyroid hormone in mice with complete deficiency of thyroid hormone receptor αProc. Nat. Acad. Sci. U.S.A.98(1)349-354(2001) 5.Videla, L.A., Cornejo, P., Romanque, P., et al.Thyroid hormone-induced cytosol-to-nuclear translocation of rat liver Nrf2 is dependent on Kupffer cell functioningSci. World J.20121-11(2012) 6.Kongpracha, P., Nagamori, S., Wiriyasermkul, P., et al.Structure-activity relationship of a novel series of inhibitors for cancer type transporter L-type amino acid transporter 1 (LAT1)J. Pharmacol. Sci.133(2)96-102(2017)