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Flutamide-d7
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Flutamide-d7图片
CAS NO:223134-72-3
包装与价格:
包装价格(元)
500µg电议
1mg电议
5mg电议

产品介绍
Flutamide-d7 是氘标记的氟他胺。
Cas No.223134-72-3
别名SCH 13521-d7
Canonical SMILESFC(F)(C1=C(C=CC(NC(C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])=O)=C1)[N+]([O-])=O)F
分子式C11H4D7F3N2O3
分子量283.3
溶解度Methanol: soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Flutamide-d7is intended for use as an internal standard for the quantification of flutamide by GC- or LC-MS. Flutamide is an androgen receptor antagonist (Kis = 1.3 and 7.5 µM for the cytosolic rat ventral prostate and anterior pituitary receptors, respectively) and prodrug form of 2-hydroxy flutamide .1Flutamide is converted to 2-hydroxy flutamide by the cytochrome P450 (CYP) isoform CYP1A2 in human liver microsomes.1It is cytotoxic to PC3 and LNCaP prostate cancer cells with IC50values of 98.8 and 81.8 µM, respectively.2Flutamide (50 mg/kg per day) reduces tumor growth in a PC-82 mouse xenograft model.3Formulations containing flutamide have been used in the treatment of prostate cancer.

1.Shet, M.S., McPhaul, M., Fisher, C.W., et al.Metabolism of the antiandrogenic drug (flutamide) by human CYP1A2Drug Metab. Dispos.25(11)1298-1303(1997) 2.Shi, Q., Wada, K., Ohkoshi, E., et al.Antitumor agents 290. Design, synthesis, and biological evaluation of new LNCaP and PC-3 cytotoxic curcumin analogs conjugated with anti-androgensBioorg. Med. Chem.20(13)4020-4031(2012) 3.Nnane, I.P., Long, B.J., Ling, Y.Z., et al.Anti-tumour effects and pharmacokinetic profile of 17-(5'-isoxazolyl)androsta-4,16-dien-3-one (L-39) in mice: An inhibitor of androgen synthesisBr. J. Cancer83(1)74-82(2000)