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5β-Tetrahydrocortisol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
5β-Tetrahydrocortisol图片
CAS NO:53-02-1
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
An endogenous metabolite of cortisol
Cas No.53-02-1
Canonical SMILESC[C@@]12[C@](CC[C@]2(O)C(CO)=O)([H])[C@@]3([H])[C@@]([C@H](C1)O)([H])[C@@]4([C@](C[C@@H](CC4)O)([H])CC3)C
分子式C21H34O5
分子量366.5
溶解度Chloroform: 10 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

5β-Tetrahydrocortisol is an endogenous metabolite of hydrocortisone .1,2It is also an intermediate in the biosynthesis of β-cortol .2It is formed from cortisol by steroid 5β-reductase and is dehydrogenated by 20β-hydroxysteroid dehydrogenase (20β-HSD) to produce β-cortol in the liver.3,1,2Urinary levels of 5β-tetrahydrocortisol have been used as a marker for cortisol production and are associated with metabolic syndrome in obese individuals.4

1.Shackleton, C.H.L.Role of a disordered steroid metabolome in the elucidation of sterol and steroid biosynthesisLipids47(1)1-12(2012) 2.Schiffer, L., Barnard, L., Baranowski, E.S., et al.Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive reviewJ. Steroid Biochem. Mol. Biol.194105439(2019) 3.Kosicka, K., Siemi?tkowska, A., Pa?ka, D., et al.Detailed analysis of cortisol, cortisone and their tetrahydro- and allo-tetrahydrometabolites in human urine by LC-MS/MSJ. Pharm. Biomed. Anal.140174-181(2017) 4.Baudrand, R., Campino, C., Carvajal, C.A., et al.Increased urinary glucocorticoid metabolites are associated with metabolic syndrome, hypoadiponectinemia, insulin resistance and β cell dysfunctionSteroids76(14)1575-1581(2011)