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AZ-GHS-22
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AZ-GHS-22图片
CAS NO:1143020-91-0
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
AZ-GHS-22 是一种有效的、非 CNS 渗透性 GHS-R1a 反向激动剂 (IC50=0.77 nM)。
Cas No.1143020-91-0
Canonical SMILESO=C(NC1=NC2=C(S1)C=C(S(=O)(CCCN3CCN(CC3)C)=O)C=C2)NC(C4=CC(N5CCOCC5)=CC=C4Cl)=O
分子式C27H33ClN6O5S2
分子量621.2
溶解度0.1 M HCl: 25 mg/ml,DMSO: 50 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

AZ-GHS-22 is an inverse agonist of the growth hormone secretagogue receptor 1a (GHS-R1a), which is also known as the ghrelin receptor.1It binds to GHS-R1a with an IC50value of 0.77 nM. AZ-GHS-22 decreases food intake in mice by 54% in the first two hours after administration of a 100 mg/kg dose.

1.McCoull, W., Barton, P., Brown, A.J.H., et al.Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonistsJ. Med. Chem.57(14)6128-6140(2014)