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Alyssin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Alyssin图片
CAS NO:646-23-1
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
在十字花科蔬菜中发现的 Alyssin 通过增加细胞内活性氧和微管蛋白解聚作用在 HepG2 中发挥抗癌活性。
Cas No.646-23-1
Canonical SMILESO=S(CCCCCN=C=S)C
分子式C7H13NOS2
分子量191.3
溶解度Chloroform: soluble,DMSO: soluble,Ethanol: soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Alyssin is an isothiocyanate that has been found inW. japonicaand has diverse biological activities, including antibacterial, fungicidal, CYP inhibitory, and antiproliferative properties.1,2,3It is active against the bacteriaB. subtilis, methicillin-sensitiveS. aureus, methicillin-resistantS. aureus(MRSA), andE. coli, and the plant pathogenic fungusA. niger.1Alyssin (0.5-2.5 µM) directly inhibits activity of the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2 induced by the polycyclic aromatic hydrocarbons (PAHs) anthracene and dibenzo[a,h]anthracene in MCF-7 breast cancer cells.2It inhibits proliferation of HCT116 colon cancer cells (IC50=<4 µm).3Alyssin also inhibits platelet aggregation induced by ADP or arachidonic acid (IC50s = 168 and 20 µM, respectively).4

1.Masuda, H., Harada, Y., Kishimoto, N., et al.Antimicrobial Activities of IsothiocyanatesAroma Active Compounds in Foods229-250(2001) 2.Skupinska, K., Misiewicz-Krzeminska, I., Lubelska, K., et al.The effect of isothiocyanates on CYP1A1 and CYP1A2 activities induced by polycyclic aromatic hydrocarbons in Mcf7 cellsToxicol. In Vitro23(5)763-771(2009) 3.Kim, M.J., Kim, S.H., and Lim, S.-J.Comparison of the apoptosis-inducing capability of sulforaphane analogues in human colon cancer cellsAnticancer Res.30(9)3611-3619(2010) 4.Morimitsu, Y., Hayashi, K., Nakagawa, Y., et al.Antiplatelet and anticancer isothiocyanates in Japanese domestic horseradish, WasabiMech. Ageing Dev.116(2-3)125-134(2000)