| CAS NO: | 2412902-55-5 |
| 包装 | 价格(元) |
| 500 μg | 电议 |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| Cas No. | 2412902-55-5 |
| Canonical SMILES | NC(C1=CC(OCCCOC)=C(N(CCCNC(OCC2=CC=CC=C2)=O)C(NC(C3=CC(C)=NN3CC)=O)=N4)C4=C1)=O |
| 分子式 | C30H37N7O6 |
| 分子量 | 591.7 |
| 溶解度 | DMF: 10mg/mL,DMF:PBS (pH 7.2) (1:2): 0.3mg/mL,DMSO: 5mg/mL,Ethanol: 0.3mg/mL |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | CAY10748 is an agonist of stimulator of interferon genes (STING; IC50= 0.3794 µM in a competition binding assay).1It activates STING in STING-expressing, but not STING knockout, THP-1 cells (EC50s = 0.287 and >100 µM, respectively, in a reporter assay). It induces phosphorylation of STING at the serine in position 366, as well as phosphorylation of TBK1 and IFN regulatory factor 3 (IRF3), indicating activation of the STING-TBK1-IRF3 signaling pathway. CAY10748 increases the secretion of IFN-β and the levels of chemokine (C-X-C motif) ligand 10 (CXCL10), and IL-6 in peripheral blood mononuclear cells (PBMCs) when used at a concentration of 10 µM. It also reduces tumor growth in a CT26 murine colon cancer model when administered at a dose of 0.15, but not 1.5, mg/kg. 1.Xi, Q., Wang, M., Jia, W., et al.Design, synthesis, and biological evaluation of amidobenzimidazole derivatives as stimulator of interferon genes (STING) receptor agonistsJ. Med. Chem.63(1)260-282(2019) |
m.cnreagent.com