您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Dienogest-d8
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Dienogest-d8
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dienogest-d8图片
CAS NO:2376035-92-4
包装:1mg
市场价:6789元

产品介绍
An internal standard for the quantification of dienogest
Cas No.2376035-92-4
Canonical SMILESO=C1C([2H])([2H])CC2=C3[C@@]([C@@](CC[C@@]4(O)C([2H])([2H])C#N)([H])[C@]4(C)CC3([2H])[2H])([2H])CCC2=C1[2H]
分子式C20H17D8NO2
分子量319.5
溶解度Chloroform: slightly soluble,Methanol: slightly, sonicated
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Dienogest-d8is intended for use as an internal standard for the quantification of dienogest by GC- or LC-MS. Dienogest is a synthetic progestin and progesterone receptor (PR) agonist (EC50s = 3.4-10.5 nM in transactivation assays).1It is selective for PR over estrogen receptor α (ERα) and ERβ, as well as glucocorticoid and mineralocorticoid receptors (EC50s = >3,000 nM for all), as well as sex hormone-binding globulin (SHBG) and cortisol-binding globulin (CBG; IC50s = 900-950 and 7,970 nM, respectively, in radioligand binding assays). It also inhibits dihydrotestosterone-induced transactivation of the androgen receptor (EC50s = 420.6-775 nM). Dienogest (0.1, 0.3, and 1 mg/kg per day for 21 days, p.o.) reduces lesion formation in a rat model of endometriosis.2It reduces 17β-estradiol benzoate-dependent tumor growth in an MCF-7 ovariectomized mouse xenograft model when administered at doses of 0.1 and 1 mg/kg per day for 28 days.3Formulations containing dienogest in combination with estradiol valerate have been used as contraceptives.

1.Sasagawa, S., Shimizu, Y., Kami, H., et al.Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharmacokinetic profileSteroids73(2)222-231(2008) 2.Katsuki, Y., Takano, Y., Futamura, Y., et al.Effects of dienogest, a synthetic steroid, on experimental endometriosis in ratsEur. J. Endocrinol.138(2)216-226(1998) 3.Katsuki, Y., Shibutani, Y., Aoki, D., et al.Dienogest, a novel synthetic steroid, overcomes hormone-dependent cancer in a different manner than progestinsCancer79(1)169-176(1997)