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N-Nitroso-N-methyl-4-Aminobutyric Acid
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
N-Nitroso-N-methyl-4-Aminobutyric Acid图片
CAS NO:61445-55-4
包装与价格：
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
A tobacco-specific nitrosamine carcinogen
Cas No.61445-55-4
别名氯沙坦基因毒杂质
Canonical SMILESOC(CCCN(C)N=O)=O
分子式C5H10N2O3
分子量146.1
溶解度DMF: 30mg/mL,DMF:PBS (pH 7.2) (1:7): 0.12mg/mL,DMSO: 20mg/mL,Ethanol: 25mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

N-Nitroso-N-methyl-4-aminobutyric acid (NMBA) is a tobacco-specific nitrosamine carcinogen.1It is oxidized to the reactive metabolite methyl-2-oxopropylnitrosamine (MOPN) in isolated rat liver mitochondria.2NMBA induces bladder transitional cell carcinomas in rats when administered in the drinking water at a concentration of 300 mg/L per day.3

1.Djordjevic, M.V., Brunnemann, K.D., and Hoffmann, D.Identification and analysis of a nicotine-derived N-nitrosamino acid and other nitrosamino acids in tobaccoCarcinogenesis10(9)1725-1731(1989) 2.Janzowski, C., Landsiedel, R., GÖlzer, P., et al.Mitochondrial formation of β-oxopropyl metabolites from bladder carcinogenic ω-carboxyalkylnitrosaminesChem. Biol. Interact.90(1)23-33(1994) 3.Lijinsky, W., Reuber, M.D., Saavedra, J.E., et al.Carcinogenesis in F344 rats by N-nitrosomethyl-n-propylamine derivativesJ. Natl. Cancer Inst.70(5)959-963(1983)