trans-Resveratrol-d₄is intended for use as an internal standard for the quantification oftrans-resveratrol by GC- or LC-MS.trans-Resveratrol is a polyphenolic phytoalexin found in a variety of plants, including grapes, that has anti-inflammatory, antioxidant, and anticancer activities.^1,2It inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC₅₀s = 15 and 3.7 μM, respectively), but not COX-2 (EC₅₀s = >100 μM and 85 μM, respectively).¹trans-Resveratrol (3 and 8 mg/kg) inhibits carrageenan-induced paw edema in mice. It inhibits free radical formation in HL-60 human promyelocytic leukemia cells induced by phorbol 12-myristate 13-acetate .trans-Resveratrol (1-25 μmol) reduces both the incidence and number of tumors in a two-stage mouse model of skin cancer induced by TPA and 7,12-dimethyl-benz[a]anthracene (DMBA).trans-Resveratrol (200 μM) also activates sirtuin 1 (SIRT1) by 8-foldin vitroand inhibits a variety of targets including ERK1, JNK1, Src, PKCα, aromatase/CYP19, and DNA polymerases α and δ (IC₅₀s = 37, 50, 20,<10, 25, 3.3, and 5 μM, respectively)in vitroand/orex vivo.^3,2It prolongs lifespan in model organisms includingC. elegans, D. melanogaster, and mice.²

1.Jang, M., Cai, L., Udeani, G.O., et al.Cancer chemopreventive activity of resveratrol, a natural product derived from grapesScience275(5297)218-220(1997) 2.Pirola, L., and FrÖjdÖ, S.Resveratrol: One molecule, many targetsIUMBM Life60(5)323-332(2008) 3.Borra, M.T., Smith, B.C., and Denu, J.M.Mechanism of human SIRT1 activation by resveratrolJ. Biol. Chem.280(17)17187-17195(2005)