CAS NO: | 207399-07-3 |
包装 | 价格(元) |
500mg | 电议 |
1g | 电议 |
Cas No. | 207399-07-3 |
别名 | IR-780碘化物 |
Canonical SMILES | ClC1=C(/C=C/C2=[N+](CCC)C3=C(C2(C)C)C=CC=C3)CCC/C1=C\C=C4N(CCC)C5=C(C/4(C)C)C=CC=C5.[I-] |
分子式 | C36H44ClN2•I |
分子量 | 667.1 |
溶解度 | Chloroform: 10 mg/ml,DMF: slightly soluble,DMSO: slightly soluble,Ethanol: slightly soluble |
储存条件 | Store at -20℃ |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | IR 780 is a heptamethine cyanine fluorescent probe forin vivoimaging of tumor cells.1It displays excitation/emission maxima of 780/799 nm, respectively.2IR 780 is transported into tumor cells, an effect that can be blocked by the organic anion transporting polypeptide (OATP) inhibitor sulfobromophthalein , and targeted to the mitochondria.1It has an additive effect on the increase in reactive oxygen species (ROS) production induced by sonodynamic therapy (SDT) in 4T1 breast cancer cells when used at a concentration of 16 µM.3IR 780 (0.2 mg/kg, i.v.) preferentially accumulates in tumor tissue in MCF-7, HeLa, and MG-63 mouse xenograft models and in a syngeneic mouse model of chemically induced lung tumors, and its fluorescence is detectable for up to 20 days. It also has an additive effect on the SDT-induced reduction in tumor growth in an 4T1 murine mammary carcinoma model. IR 780 has been incorporated into heparin-folic acid-IR 780 nanoparticles for use in photothermal therapy.4 1.Zhang, C., Liu, T., Su, Y., et al.A near-infrared fluorescent heptamethine indocyanine dye with preferential tumor accumulation for in vivo imagingBiomaterials31(25)6612-6617(2010) |