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PCI 45227
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PCI 45227图片
CAS NO:1654820-87-7
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
PCI 45227 (PCI-45227) 是依鲁替尼的二氢二醇活性代谢物,对 BTK 的抑制活性比依鲁替尼低约 15 倍。
Cas No.1654820-87-7
别名依鲁替尼代谢物,PCI-45227
Canonical SMILESO=C(C(CO)O)N1CCC[C@@](C1)([H])N2N=C(C3=C2N=CN=C3N)C4=CC=C(OC5=CC=CC=C5)C=C4O=C(C(CO)O)N1CCC[C@@](C1)([H])N2N=C(C3=C2N=CN=C3N)C4=CC=C(OC5=CC=CC=C5)C=C4
分子式C25H26N6O4
分子量474.5
溶解度Methanol: soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

PCI 45227 is an active metabolite of the Bruton's tyrosine kinase inhibitor ibrutinib .1PCI 45227 is formed from ibrutinib by the cytochrome P450 (CYP) isoform CYP3A.

1.Veeraraghavan, S., Viswanadha, S., Thappali, S., et al.Simultaneous quantification of lenalidomide, ibrutinib and its active metabolite PCI-45227 in rat plasma by LC-MS/MS: Application to a pharmacokinetic studyJ. Pharm. Biomed. Anal.107151-158(2015)