您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > (-)-Cryptopleurine
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
(-)-Cryptopleurine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(-)-Cryptopleurine图片
CAS NO:482-22-4
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
An alkaloid with diverse biological activities
Cas No.482-22-4
Canonical SMILESCOC1=CC2=C3C(CN4[C@@](CCCC4)([H])C3)=C5C(C=C(C=C5)OC)=C2C=C1OC
分子式C24H27NO3
分子量377.5
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

(-)-Cryptopleurine is an alkaloid that has been found inLauraceaeand has diverse biological activities.1It inhibits the growth of human A375 melanoma, A431 epidermoid carcinoma, A549 lung, MES-SA uterine sarcoma, and MCF-7 breast cancer cells (IC50= 3 nM for all).2(-)-Cryptopleurine inhibits hypoxia-induced gene expression in a hypoxia response element (HRE) reporter assay (IC50= 8.7 nM).3(-)-Cryptopleurine (500 µg/ml) prevents lesion formation in tobacco (N. tabacum) plants infected with tobacco mosaic virus (TMV).1It also inhibits protein synthesis by yeast and mammalian ribosomes.4,5

1.Wang, Z., Feng, A., Cui, M., et al.First discovery and stucture-activity relationship study of phenanthroquinolizidines as novel antiviral agents against Tobacco Mosaic Virus (TMV)PLoS One7(12)e52933(2012) 2.Banwell, M.G., Bezos, A., Burns, C., et al.C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic propertiesBioorg. Med. Chem. Lett.16(1)181-185(2006) 3.Cai, X.F., Jin, X., Lee, D., et al.Phenanthroquinolizidine alkaloids from the roots of Boehmeria pannosa potently inhibit hypoxia-inducible factor-1 in AGS human gastric cancer cellsJ. Nat. Prod.69(7)1095-1097(2006) 4.Battaner, E., and Vazquez, D.Inhibitors of protein synthesis by ribosomes of the 80-S typeBiochim. Biophys. Acta254(2)316-330(1971) 5.Pestka, S., Rosenfeld, H., Harris, R., et al.Studies on transfer ribonucleic acid-ribosome complexes. XXI. Effect of antibiotics on peptidyl-puromycin synthesis by mammalian polyribosomesJ. Biol. Chem.247(21)6895-6900(1972)