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CP94
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CP94图片
CAS NO:115900-75-9
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
An iron chelator
Cas No.115900-75-9
别名1,2-二乙基-3-羟基吡啶-4(1H)-酮
Canonical SMILESO=C1C=CN(CC)C(CC)=C1O
分子式C9H13NO2
分子量167.2
溶解度DMF: 30 mg/ml,DMSO: 15 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CP94 is an iron chelator.1It enhances protoporphyrin IX photobleaching and decreases in the viability of A431 squamous epithelial carcinoma cells when used at a concentration of 150 µM in combination with photodynamic therapy (PDT) mediated by the protoporphyrin IX precursors aminolevulinic acid (ALA), methyl aminolevulinate (MAL), or hexylaminolevulinate .2CP94 (2 mg/ml in the drinking water) decreases hepatic total non-heme and ferritin-stored iron levels, as well as increases hepatic protoporphyrin levels, in mice.3It also reduces ferrocene-induced increases in rat brain iron levels when administered at a dose of 100 mg/kg.4

1.Dobbin, P.S., Hider, R.C., Hall, A.D., et al.Synthesis, physicochemical properties, and biological evaluation of N-substituted 2-alkyl-3-hydroxy-4(1H)-pyridinones: Orally active iron chelators with clinical potentialJ. Med. Chem.36(17)2448-2458(1993) 2.Blake, E., Allen, J., and Curnow, A.The effects of protoporphyrin IX-induced photodynamic therapy with and without iron chelation on human squamous carcinoma cells cultured under normoxic, hypoxic and hyperoxic conditionsPhotodiagnosis Photodyn. Ther.10(4)575-582(2013) 3.Smith, A.G., Clothier, B., Francis, J.E., et al.Protoporphyria induced by the orally active iron chelator 1,2-diethyl-3-hydroxypyridin-4-one in C57BL/10ScSn miceBlood89(3)1045-1051(1997) 4.Ward, R.J., Dexter, D., Florence, A., et al.Brain iron in the ferrocene-loaded rat: its chelation and influence on dopamine metabolismBiochem. Pharmacol.49(12)1821-1826(1995)