CAS NO: | 115900-75-9 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
Cas No. | 115900-75-9 |
别名 | 1,2-二乙基-3-羟基吡啶-4(1H)-酮 |
Canonical SMILES | O=C1C=CN(CC)C(CC)=C1O |
分子式 | C9H13NO2 |
分子量 | 167.2 |
溶解度 | DMF: 30 mg/ml,DMSO: 15 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml |
储存条件 | -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | CP94 is an iron chelator.1It enhances protoporphyrin IX photobleaching and decreases in the viability of A431 squamous epithelial carcinoma cells when used at a concentration of 150 µM in combination with photodynamic therapy (PDT) mediated by the protoporphyrin IX precursors aminolevulinic acid (ALA), methyl aminolevulinate (MAL), or hexylaminolevulinate .2CP94 (2 mg/ml in the drinking water) decreases hepatic total non-heme and ferritin-stored iron levels, as well as increases hepatic protoporphyrin levels, in mice.3It also reduces ferrocene-induced increases in rat brain iron levels when administered at a dose of 100 mg/kg.4 1.Dobbin, P.S., Hider, R.C., Hall, A.D., et al.Synthesis, physicochemical properties, and biological evaluation of N-substituted 2-alkyl-3-hydroxy-4(1H)-pyridinones: Orally active iron chelators with clinical potentialJ. Med. Chem.36(17)2448-2458(1993) 2.Blake, E., Allen, J., and Curnow, A.The effects of protoporphyrin IX-induced photodynamic therapy with and without iron chelation on human squamous carcinoma cells cultured under normoxic, hypoxic and hyperoxic conditionsPhotodiagnosis Photodyn. Ther.10(4)575-582(2013) 3.Smith, A.G., Clothier, B., Francis, J.E., et al.Protoporphyria induced by the orally active iron chelator 1,2-diethyl-3-hydroxypyridin-4-one in C57BL/10ScSn miceBlood89(3)1045-1051(1997) 4.Ward, R.J., Dexter, D., Florence, A., et al.Brain iron in the ferrocene-loaded rat: its chelation and influence on dopamine metabolismBiochem. Pharmacol.49(12)1821-1826(1995) |