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IM-156(acetate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
IM-156(acetate)图片
CAS NO:2043654-54-0
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
A mitochondrial complex I inhibitor and an AMPKα activator
Cas No.2043654-54-0
Canonical SMILESFC(F)(OC1=CC=C(NC(NC(N2CCCC2)=N)=N)C=C1)F.CC(O)=O
分子式C13H16F3N5O·XC2H4O2
分子量315.3
溶解度DMF: 1 mg/ml,DMSO: 1 mg/ml,Ethanol: 1 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

IM-156 is an inhibitor of mitochondrial complex I, also known as NADH dehydrogenase (IC50= 2.2 µM) and an activator of AMP-activated protein kinase α (AMPKα).1,2It reduces the oxygen consumption rate (OCR; IC50= 3.3 µM) and decreases mitochondrial ATP production in Eµ-Mycmouse lymphoma cells.1IM-156 (10, 30, and 50 µM) increases AMPKα activity in primary rat peritoneal mesothelial cells and protects against chlorhexidine-induced peritoneal fibrosis in rats when administered at a dose of 1 mg/kg.2It reduces tumor growth in an AT-84 murine oral cancer model and decreases age-related decline in novel object recognition, spatial working, and contextual memory in mice.3,4

1.Izreig, S., Gariepy, A., Kaymak, I., et al.Repression of LKB1 by miR-17~92 sensitizes MYC-dependent lymphoma to biguanide treatmentCell Rep. Med.1(2)100014(2020) 2.Ju, K.D., Kim, H.J., Tsogbadrakh, B., et al.HL156A, a novel AMP-activated protein kinase activator, is protective against peritoneal fibrosis in an in vivo and in vitro model of peritoneal fibrosisAm. J. Physiol. Renal. Physiol.310(5)F342-F350(2016) 3.Lam, T.G., Jeong, Y.S., Kim, S.-A., et al.New metformin derivative HL156A prevents oral cancer progression by inhibiting the insulin-like growth factor/AKT/mammalian target of rapamycin pathwaysCancer Sci.109(3)699-709(2018) 4.Bang, E., Lee, B., Park, J.-O., et al.The improving effect of HL271, a chemical derivative of metformin, a popular drug for type II diabetes mellitus, on aging-induced cognitive declineExp. Neurobiol.27(1)45-56(2018)