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Phenformin-d5(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Phenformin-d5(hydrochloride)图片
包装与价格:
包装价格(元)
500 µg电议
1mg电议
5mg电议
10mg电议

产品介绍
An internal standard for the quantification of phenformin
别名Phenethylbiguanide-d5 hydrochloride
Canonical SMILESN=C(NC(NCCC1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])=N)N.Cl
分子式C10H10D5N5• HCl
分子量246.8
溶解度DMF: 33 mg/mL,DMSO: 33 mg/mL,Ethanol: 10 mg/mL,PBS (pH 7.2): 5mg/mL
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Phenformin-d5is intended for use as an internal standard for the quantification of phenformin by GC- or LC-MS. Phenformin is an antihyperglycemic biguanide.1It reduces blood glucose levels in a mouse model of diabetes induced by alloxan when administered at a dose of 100 mg/kg. Phenformin (250 mg/kg) induces lactic acidosis in diabetic dogs.2It also inhibits tumor growth of MCF-7 and MDA-MB-231 breast cancer mouse xenograft models when administered at a dose of 300 mg/kg.3Formulations containing phenformin were previously used in the treatment of diabetes mellitus.

1.Li, W.-L., Wu, J.-L., Ren, B.-R., et al.Pharmacological studies on anti-hyperglycemic effect of folium eriobotryaeAm. J. Chin. Med.35(4)705-711(2007) 2.Arieff, A.I., Park, R., Leach, W.J., et al.Pathophysiology of experimental lactic acidosis in dogsAm. J. Physiol.239(2)F135-F142(1980) 3.Appleyard, M.V.C.L., Murray, K.E., Coates, P.J., et al.Phenformin as prophylaxis and therapy in breast cancer xenograftsBr. J. Cancer106(6)1117-1122(2012)