| 包装 | 价格(元) |
| 500 µg | 电议 |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 别名 | Phenethylbiguanide-d5 hydrochloride |
| Canonical SMILES | N=C(NC(NCCC1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])=N)N.Cl |
| 分子式 | C10H10D5N5• HCl |
| 分子量 | 246.8 |
| 溶解度 | DMF: 33 mg/mL,DMSO: 33 mg/mL,Ethanol: 10 mg/mL,PBS (pH 7.2): 5mg/mL |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Phenformin-d5is intended for use as an internal standard for the quantification of phenformin by GC- or LC-MS. Phenformin is an antihyperglycemic biguanide.1It reduces blood glucose levels in a mouse model of diabetes induced by alloxan when administered at a dose of 100 mg/kg. Phenformin (250 mg/kg) induces lactic acidosis in diabetic dogs.2It also inhibits tumor growth of MCF-7 and MDA-MB-231 breast cancer mouse xenograft models when administered at a dose of 300 mg/kg.3Formulations containing phenformin were previously used in the treatment of diabetes mellitus. 1.Li, W.-L., Wu, J.-L., Ren, B.-R., et al.Pharmacological studies on anti-hyperglycemic effect of folium eriobotryaeAm. J. Chin. Med.35(4)705-711(2007) 2.Arieff, A.I., Park, R., Leach, W.J., et al.Pathophysiology of experimental lactic acidosis in dogsAm. J. Physiol.239(2)F135-F142(1980) 3.Appleyard, M.V.C.L., Murray, K.E., Coates, P.J., et al.Phenformin as prophylaxis and therapy in breast cancer xenograftsBr. J. Cancer106(6)1117-1122(2012) |
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