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CP21R7
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CP21R7图片
CAS NO:125314-13-8
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
CP21R7 是有效的 GSK-3β 抑制剂，IC50 为 1.8 nM； CP21R7 还显示出对 PKCα 的抑制活性，IC50 为 1900 nM。
Cas No.125314-13-8
别名GSK-3Β抑制剂(CP21R7),CP21
化学名3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Canonical SMILESNC1=CC=CC(C(C(N2)=O)=C(C3=CN(C)C4=C3C=CC=C4)C2=O)=C1
分子式C19H15N3O2
分子量317.3
溶解度≤1mg/ml in DMSO;1mg/ml in dimethyl formamide
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CP21R7 is a potent and selective inhibitor of GSK3β.

The glycogen synthase kinase-3β (GSK-3β), a serine/threonine, is a ubiquitous kinase that participates in a multitude of cellular processes, such as cell membrane-to-nucleus signaling, gene transcription, translation, cytoskeletal structuring and cell cycle progression and survival [1].

In vitro: CP21R7 was an inhibitor of GSK3β and PKCα with the IC50 values of 1.8 and 1900 nM, respectively [1]. In the human reporter cell line, CP21R7 potently activated canonical Wnt signallingeven at the dose of 1 μM, with highest activity seen at 3 μM [2]. In human iPSCs exposed to N2B27 medium, supplemented with 1 μM GSK3β inhibitor CP21R7 strongly upregulated the expression of T (also known as Brachyury, T/BRY), a meso-endoderm marker expressed in the primitive streak [2].

References:
[1] Gong L, Hirschfeld D, Tan Y C, et al.  Discovery of potent and bioavailable GSK-3β inhibitors[J]. Bioorganic & medicinal chemistry letters, 2010, 20(5): 1693-1696.
[2] Ciampi O, Iacone R, Longaretti L, et al.  Generation of functional podocytes from human induced pluripotent stem cells[J]. Stem cell research, 2016, 17(1): 130-139.