您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > JS-K
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
JS-K
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
JS-K图片
CAS NO:205432-12-8
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
JS-K 是一种 NO 供体,在生理 pH 值下与谷胱甘肽反应生成 NO。 JS-K 抑制 Jurkat T 急性淋巴细胞白血病细胞的增殖、诱导细胞凋亡并破坏细胞周期。
Cas No.205432-12-8
化学名4-[2-(2,4-dinitrophenoxy)-1-oxidodiazenyl]-1-piperazinecarboxylic acid, ethyl ester
Canonical SMILESO=[N](N1CCN(C(OCC)=O)CC1)=NOC(C=CC([N+]([O-])=O)=C2)=C2[N+]([O-])=O
分子式C13H16N6O8
分子量384.3
溶解度DMF: 0.5 mg/ml,DMSO: 0.3 mg/ml,Ethanol: slightly soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述 JS-K is a nitric oxide (NO) donor that reacts with glutathione to generate NO at physiological pH. It inhibits proliferation of HL-60 cells (IC50 = 0.5 uM), which is prevented by the glutathione precursor N-acetyl-L-cysteine , and inhibits growth of the solid tumor cell lines PPC-1, DLD-1, and Meth A. It decreases tumor volume by over 50% in an HL-60 mouse xenograft model when used at a dose of 4 uMol/kg, i.v., three times per week. JS-K inhibits proliferation, induces apoptosis, and disrupts the cell cycle of Jurkat T acute lymphoblastic leukemia cells. It also induces S-nitrosylation of β-catenin followed by dose-dependent degradation of nuclear β-catenin and S-nitrosylated nuclear β-catenin levels.