| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
Cell lines | Calu3 (lung epithelium) and Caco2 (intestinal epithelium) cells |
Preparation Method | Calu3 (lung epithelium) and Caco2 (intestinal epithelium) cells were infected with early passage SARS-CoV-2 pretreated with Heparan sulfate, and samples were collected 24 hours after infection. |
Reaction Conditions | 0-500ug/ml Heparan sulfate,24h |
Applications | Heparan sulfate treatment significantly reduced SARS-CoV-2 replication in cell lysates and supernatant samples of Calu3 and Caco2. |
Animal models | Sprague-Dawley male rats 3-4 months old |
Preparation Method | Groups of rats (n = 5) received a piece of Gelfoam embedded with human recombinant FGF-2 dissolved in PBS, Heparan sulfate (HS; 10 μg/ml) dissolved in PBS, or both, in the right hemispheres. |
Dosage form | A piece of Gelfoam embedded with 10 ug/ml Heparan sulfate for two days |
Applications | FGF-2/FGFR system is involved in the regulation of astrocytic reactivity and/or proliferation in the brain and its action is potentiated by Heparan sulfate. |
| 文献引用 | |
| 产品描述 | Heparan sulfate (HS) is a complex, polyanionic polysaccharide ubiquitously expressed on cell surfaces and in the extracellular matrix[1]. Heparan sulfate interacts with numerous proteins, including growth factors, morphogens, and adhesion molecules, and thereby regulates important developmental processes in invertebrates and vertebrates[6]. Heparan sulfate proteoglycans can act as receptors for proteases and protease inhibitors regulating their spatial distribution and activity. Membrane Heparan sulfate proteoglycans act as coreceptors for various tyrosine kinase-type growth factor receptors, lowering their activation threshold or changing the duration of signaling reactions[5]. Heparan sulfate treatment significantly reduced SARS-CoV-2 replication in cell lysates and supernatant samples of Calu3 and Caco2. HS serves as an essential host determinant during SARS-CoV-2 attachment and replication[2].Heparan sulfate influences the binding affinity of intestinal epithelium cells to Wnt, thereby promoting activation of canonical Wnt signaling and facilitating regeneration of small intestinal crypts after epithelial injury[7]. In Sprague-Dawley male rats, FGF-2/FGFR system is involved in the regulation of astrocytic reactivity and/or proliferation in the brain and its action is potentiated by Heparan sulfate[3].Heparan sulfate proteoglycans represent a major component of the extracellular matrix and are critical for brain development, Heparan Sulfate can maintain neuronal excitability, promote synaptic plasticity and learning[5]. References: |
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