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Saridegib(IPI-926)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Saridegib(IPI-926)图片
CAS NO:1037210-93-7
包装与价格：
包装价格(元)
5mg电议
10mg电议

产品介绍
Saridegib (IPI-926) 是一种有效且特异性的 Smoothened (Smo) 抑制剂，Smoothened (Smo) 是 Hedgehog (Hh) 通路中的关键信号跨膜蛋白。
Cas No.1037210-93-7
别名IPI-926; Patidegib
Canonical SMILESCC1=C(C[C@@]2([H])[C@@]3([H])CC[C@@]4([H])[C@]2(C)CC[C@@H](NS(C)(=O)=O)C4)[C@@]3([H])CC[C@@]([C@@H]5C)(C1)O[C@@]6([H])[C@@]5([H])NC[C@@H](C)C6
分子式C29H48N2O3S
分子量504.77
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.

Evidence from a genetically engineered mouse model of pancreatic cancer demonstrates that Saridegib (IPI-926) can deplete tumor-associated stromal tissue and increase intratumoral mean vessel density. These changes result in enhanced delivery of concurrently administered systemic agents, leading to a decreased tumor burden and prolonged survival in this mouse model[1].

[1]. Ko AH, et al. A Phase I Study of FOLFIRINOX Plus IPI-926, a Hedgehog Pathway Inhibitor, for Advanced Pancreatic Adenocarcinoma. Pancreas. 2016 Mar;45(3):370-5.