| CAS NO: | 2234281-75-3 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| Cas No. | 2234281-75-3 |
| Canonical SMILES | O=C(NCCC1=CC=CC=C1OCC)/C=C/C2=CNC3=C2C=CC=C3OC |
| 分子式 | C22H24N2O3 |
| 分子量 | 364.44 |
| 溶解度 | DMSO : 125 mg/mL (342.99 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | JI051 is a stabilizer for the Hes1-PHB2 interaction, interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity[1]. JI051 causes G2/M cell-cycle arrest[1].JI051 (0.1-10 µM, 24 hours) significantly inhibits cell proliferation of HEK293 cells, with an EC50 of 0.3 μM[1]. Cell Proliferation Assay[1] Cell Line: HEK293 cells [1]. Perron A, et al. Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone. J Biol Chem. 2018 May 25;293(21):8285-8294. |
m.cnreagent.com