Retreversine 是 Reversine 的非活动控件。 Reversine 是一类新型的 ATP 竞争性 Aurora 激酶抑制剂。
| Cas No. | 1028332-91-3 |
| Canonical SMILES | C1CCC(CC1)Nc1nc(Nc2ccc(cc2)N2CCOCC2)c2nc[nH]c2n1 |
| 分子式 | C21H27N7O |
| 分子量 | 393.5 |
| 溶解度 | DMF: 1.6 mg/ml,DMSO: 2.5 mg/ml,DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Terminal differentiation of embryonic progenitor cells to form distinct, adult tissues is the hallmark of organogenesis in complex organisms. However, in mammals including humans, this process is not readily reversible. Reversine is a 2,6-disubstituted purine derivative that was identified using a screening system based on the loss of terminal differentiation markers in C2C12 myoblast cells. Retreversine is an inactive control molecule, created by simply interchanging the 2 and 6-substituents on the purine ring. Retreversine is inactive at 10-fold higher concentrations than reversine in the myoblast assay. |
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