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Hedgehog Antagonist VIII
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Hedgehog Antagonist VIII图片
CAS NO:330796-24-2
包装与价格:
包装价格(元)
500μg电议
1mg电议
5mg电议
10mg电议

产品介绍
Cas No.330796-24-2
Canonical SMILESO=C1C2=CC=CC=C2N=C(CNC(NC3=CC=C(Cl)C(C(F)(F)F)=C3)=O)N1C4=CC=C(F)C=C4
分子式C23H15ClF4N4O2
分子量490.8
溶解度DMF: 30 mg/ml,DMF:PBS(pH7.2) (1:2): 0.3 mg/ml,DMSO: 25 mg/ml,Ethanol: 10 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers, including glioblastoma, for which the Gli proteins are named. Hh antagonist VIII is a cell-permeable quinazolinyl-urea compound that has been shown to inhibit Gli transcription activity with an IC50 value of 70 nM.