LLP-3 是一种有效的 Survivin 抑制剂，可破坏癌细胞中的 Survivin-Ran 相互作用。 LLP-3可用于多形性胶质母细胞瘤（GBM）的研究。
| Cas No. | 1453835-43-2 |
| Canonical SMILES | O=C1NC(C2=C(O)C=CC(Cl)=C2)=CC(C3=CC(OCC4=CC=CC=C4)=CC(OCC5=CC=CC=C5)=C3)=C1C#N |
| 分子式 | C32H23ClN2O4 |
| 分子量 | 535 |
| 溶解度 | DMF: 2 mg/ml,DMF:PBS(pH7.2) (1:2): 0.3 mg/ml,DMSO: 2 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Survivin (also known as baculoviral IAP repeat-containing protein 5 (BIRC5)) is a member of the inhibitor of apoptosis (IAP) family that interacts with and inhibits the apoptotic function of several proteins. LLP-3 is a cell-permeable ligand of Survivin that blocks its interaction with Ran, resulting in the induction of apoptosis (IAP) in glioma stem cells (IC50 = 31 µM). It abolishes the growth of glioblastoma multiforme cell in spheres and in tumor slice cultures. |
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