PF-5006739

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PF-5006739

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1293395-67-1

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议

产品介绍

PF-5006739 是一种有效，选择性 CK1δ/ε 抑制剂，IC50 分别为 3.9 nM 和 17.0 nM。 PF-5006739 是一系列精神疾病的潜在治疗剂，具有低纳摩尔的 CK1δ/ε 体外效力和高激酶组选择性。PF-5006739 以剂量依赖的方式减弱动物啮齿动物恢复模型中的阿片类药物寻找行为。PF-5006739 改善了饮食诱导的肥胖 (DIO) 和遗传的 (ob/ob) 小鼠模型中的葡萄糖耐量。

Cas No.	1293395-67-1
Canonical SMILES	NC1=NC=CC(C2=C(C3=CC=C(F)C=C3)N=CN2C4CCN(CC5=NOC=C5)CC4)=N1
分子式	C₂₂H₂₂FN₇O
分子量	419.45
溶解度	Soluble in DMSO
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	PF-5006739 is a potent and selective inhibitor of CK1δ/ε with IC50s of 3.9 nM and 17.0 nM, respectively. PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1δ/ε and high kinome selectivity. PF-5006739 attenuats opioid drug-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent manner[1]. PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity[2]. CK1δ\|3.9 nM (IC50)\|CK1?\|17.0 nM (IC50) [1]. Wager TT, et al. Casein kinase 1δ/ε inhibitor PF-5006739 attenuates opioid drug-seeking behavior. ACS Chem Neurosci. 2014 Dec 17;5(12):1253-65. [2]. Cunningham PS, et al. Targeting of the circadian clock via CK1δ/ε to improve glucose homeostasis in obesity.Sci Rep. 2016 Jul 21;6:29983.