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SAHM1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SAHM1图片
CAS NO:2050906-89-1
包装:1mg
市场价:4616元

产品介绍
SAHM1 是一种类似于主脑样 (MAML) 的显性阴性形式的肽模拟物,可抑制典型的 Notch 转录复合物形成。
Cas No.2050906-89-1
分子式C94H162N36O23S
分子量2196.58
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Notch pathway inhibitor - stabilized hydrocarbon-stapled alpha helical peptide. Targets the protein-protein interface and prevents Notch complex assembly.

Ashley et al (2015) Notch signaling promotes osteoclast maturation and resorptive activity. J Cell Biochem 116 2598 PMID:25914241 |Bagheri et al (2018) Notch pathway is active during osteogenic differentiation of human bone marrow mesenchymal stem cells induced by pulsed electromagnetic fields. J.Tissue Eng.Regen.Med. 12 304 PMID:28482141 |KleinJan et al (2018) The Notch pathway inhibitor stapled a-helical peptide derived from mastermind-like 1 (SAHM1) abrogates the hallmarks of allergic asthma. J.Allergy Clin.Immunol. 142 76 PMID:29111218