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Lats-IN-1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Lats-IN-1图片
CAS NO:1424635-83-5
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Lats-IN-1是一种高效的，ATP竞争性的Lats1和Lats2激酶抑制剂。Lats-IN-1能促进有丝分裂后哺乳动物组织的Yap依赖性增殖。
Cas No.1424635-83-5
Canonical SMILESO=C(C1=CNC2=NC=CC=C12)/N=C(SC=C3)/N3CC4=CC=CC=C4
分子式C18H14N4OS
分子量334.39
溶解度DMSO: 83.33 mg/mL (249.20 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Lats-IN-1 is a potent and ATP-competitive inhibitor of Lats1 and Lats2 kinases. Lats-IN-1 promotes Yap-dependent proliferation in postmitotic mammalian tissues[1].

The IC50 for Lats-IN-1 increases with the ATP concentration[1].Lats-IN-1 (10 μM; 24 hours) interferes with the ability of Lats kinases to phosphorylate Yap, with an EC50 of 510 nM[1].Lats-IN-1 causes Yap-dependent proliferation of murine supporting cells in the inner ear, murine cardiomyocytes, and human MÜller glia in retinal organoids[1].Lats-IN-1 fosters both the G1-S and G2-M checkpoint transitions and yields supporting cells capable of transdifferentiation[1]. Cell Proliferation Assay[1] Cell Line: MCF 10A cells

[1]. Nathaniel Kastan, et al. Small-molecule inhibition of Lats kinases promotes Yap-dependent proliferation in postmitotic mammalian tissues. bioRxiv 2020.02.11.944157.