| CAS NO: | 3073-59-4 |
| 包装 | 价格(元) |
| 25 g | 电议 |
| 50 g | 电议 |
六亚甲基双乙酰胺是一种肿瘤细胞分化剂。
| Cas No. | 3073-59-4 |
| 别名 | N,N'-六亚甲基双乙酰胺,HMBA |
| Canonical SMILES | CC(NCCCCCCNC(C)=O)=O |
| 分子式 | C10H20N2O2 |
| 分子量 | 200.3 |
| 溶解度 | DMF: 5 mg/ml,DMSO: 10 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): 10 mg/ml |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 文献引用 | |
| 产品描述 | Hexamethylene bisacetamide is a tumor cell-differentiating agent.1It induces complete differentiation of 754A murine erythroleukemia cells when used at a concentration of 5 mM. Hexamethylene bisacetamide also induces latent HIV-1 viral production in chronically HIV-1-infected U1 cells in a concentration-dependent manner.2Implantation of HT-29 colon cancer cells cultured with hexamethylene bisacetamide for seven, but not 28, days reduces tumorigenesis of those cells in mice.3 1.Reuben, R.C., Wife, R.L., Breslow, R., et al.A new group of potent inducers of differentiation in murine erythroleukemia cellsProc. Natl. Acad. Sci. USA73(3)862-866(1976) 2.Contreras, X., Barboric, M., Lenasi, T., et al.HMBA releases P-TEFb from HEXIM1 and 7SK snRNA via PI3K/Akt and activates HIV transcriptionPLoS Pathog.3(10)1459-1469(2007) 3.Schroy, P., Winawer, S., and Friedman, E.Effect on in vivo tumorigenicity of lengthy exposure of human colon cancer cells to the differentiation agent hexamethylene bisacetamideCancer Lett.48(1)53-58(1989) |
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